ea0002p61 | Neuroendocrinology | SFE2001
Pyle M
, Jordan S
, Gueorguiev M
, Meinhardt A
, Metz C
, Bucala R
, Korbonits M
, Grossman A
MIF can override the anti-inflammatory actions of glucocorticoids during immune response, and thus is an important pro-inflammatory factor. The presence of MIF in the cytoplasm of adenomatous cells of the anterior pituitary has been described, and high levels of MIF in other rapidly-proliferating tissues have been demonstrated. It is hypothesized that MIF release from these cells is influenced by the hypothalamo-pituitary-adrenal axis, and that ACTH and MIF are released simult...